Nano-DHLA (Liquid) (2 fl oz)

DHLA: The Spectacular Antioxidant
DHLA (dihydrolipoic acid) is unique as an antioxidant due to its spectacular effectiveness in quenching every known free radical that occurs in living tissue, including both fat and water soluble tissues. No other antioxidant has this incredible capability. DHLA is readily absorbed orally and has very low toxicity. It has unequalled potential as a highly effective therapeutic agent in clinical conditions associated with free radical damage such as Parkinson's disease, Alzheimer's disease and other neurodegenerative illnesses.

Until 2003, DHLA in a stabilized form was not available.
DHLA could only be obtained indirectly through consuming ALA (alpha lipoic acid) which in turn, was converted by the body into small amounts of DHLA. However, this process did not deliver a significant or reliable supply of DHLA. Research studies have attempted to measure the effect of DHLA on cellular tissue using indirect methods based on ALA consumption. As a result, DHLA is known to be a powerful electron donor to other compounds. Ascorbic acid and indirectly vitamin E are regenerated by DHLA. Studies found that the oxidized form of DHLA, ALA, increased intracellular glutathione. DHLA was shown to regenerate coenzyme CoQ10, glutathione and NADPH or NADH and by this mechanism, increase cellular ATP production. The oxidized form of DHLA, ALA, also assists in the conversion of pyruvate to acetyl-coenzyme A, the beginning point of the Krebs cycle which produces the high energy molecule ATP.

Radical Synthetic vs. "Once Living" Sources
ALA, R-lipoic acid or DHLA that are derived from synthetic sources can never match natural source counterparts in the ability to sustain and repair the DNA of the cell. A natural ("once living") source is comprised of dynamic, complex processes where each molecule contains atoms that generate photons, or in other words, pure light. The photonic field around each molecule creates a "body of light" which surrounds all living substances. Only nutrients derived from a "once living" source are capable of upgrading cellular DNA, according to quantum physics researcher and expert, Dr. Fritz-Albert Popp.

On the other hand, synthetic source nutrients may provide initial cellular benefits, but over time, they act to accelerate the degeneration of DNA, ending in earlier cell death. Synthetic nutrients initially stimulate the cell to accomplish work which may appear to be beneficial, but long-term, the DNA and cellular degradation cannot justify the initial benefits. Consequently, using ALA derived from a synthetic source can defeat the purpose of using an ALA supplement to live longer more healthfully. Not only has a stable form of DHLA been badly needed, but also a DHLA source that has been derived from a "once living" source so it is capable of imparting significant, long-term DNA protection and cellular benefits.

Scavenger of Free Radicals
Lester Packer, PhD, of the University of California at Berkeley, has shown that ALA is a powerful free radical quencher and metal chelating agent. It helps regenerate other antioxidants and favorably affects gene expression. (1) Experts are in general agreement that ALA can scavenge the hydroxyl radical, hypochlorous acid radical, and singlet oxygen radical, but not the peroxyl or superoxide anion free radical. (1, 5-7)

Arsenic Protection
Research has shown that ALA can protect mice from poisoning by sodium arsenite, an arsenical herbicide, insecticide and rodenticide by a ratio of ALA to arsenite of at least 8:1. The mice were protected even if the administration of ALA was given after onset of severe symptoms of poisoning.

Mercury Protection
Further research has demonstrated that ALA removed mercury from renal slices (kidney). (14) ALA was also shown to dramatically increase biliary excretion of injected mercury while decreasing cadmium, zinc, copper and methylmercury excretion. (15)

Cadmium Protection
In another study, ALA and R-lipoic acid were shown more effective than S-lipoic acid (which occurs only in synthetic ALA) in metal chelation. In isolated hepatocytes (liver cells), ALA reduced cadmium induced toxicity. However, DHLA was much more effective than ALA. ALA (and therefore DHLA at least as much or more) was shown to provide significant liver protection against cadmium toxicity, even under glutathione depleted experimental conditions. Another study showed ALA completely prevented cadmium induced lipid peroxidation in the brain, heart and testicles in rats.

Restoration of Metabolism and Mobility
R-lipoic acid supplementation reversed the age related, declining ability of rats to respond to increased oxidative stress. The age decline was almost completely reversed on a two week dietary supplementation of R-lipoic acid. When fed to old rats, R-lipoic acid showed complete reversal of declining levels of glutathione and ascorbic acid in hepatocytes. In addition, the metabolic rate and mobility of the old rats were also restored to that of youthful rats.

Improvement in Type II Diabetes
Since the year 2000, about 80% of all type II diabetes is now believed to be linked to infection. Type II diabetes is now at epidemic proportions with 900,000 new cases per year in the U.S. The infectious process produces large amounts of free radicals. One marker of free radical damage common to Type II diabetes is AGEs (advanced glycation end products). Glycation of protein can be caused by elevated blood and tissue glucose. Packer and Kawabata showed that noncovalent binding of ALA to albumin protects protein from glycation.

Other studies using ALA in Type II diabetes have shown improvement in insulin metabolism. Nerve damage (polyneuropathies) is common in diabetes and has been successfully treated with ALA in Germany for more than 20 years. Findings show that ALA administration yielded excellent results: albuminuria decreased 50%, and neuropeptide deficits, nerve blood flow and neurological symptoms all improved.

Glaucoma Improvement
In one glaucoma study, stage I and IIOAG (open-angle glaucoma) patients were assigned to one of 3 groups: no ALA, 75 mg or 150 mg ALA daily for 2 months. The greatest improvement in visual function, efficacy of liquid discharge and biochemical markers were observed in the group receiving the higher dose of ALA.

Benefits of Stabilized DHLA
The above clinical research studies using synthetically-derived ALA had obviously spectacular physiological benefits. However, as has been emphasized earlier, these benefits are not without a price to pay, namely, the eventual degradation of the cellular DNA which occurs during long-term use of synthetic compounds.

Advantages of Natural-Source DHLA
Stabilized DHLA (natural-source) may prove to be one of the most significant antioxidant compounds ever created, since it can accomplish all the feats attributed to ALA and more, but without ALA's negative effects. In fact, some authors believe that the benefits ascribed to ALA are in fact, actually due to the internal generation of DHLA (after ALA consumption). For the very first time, stabilized DHLA is now available that can offer significant and reliable amounts of DHLA, without the need to consume synthetic precursors.

DNA and Nerve Protection
Stabilized DHLA can provide exquisite neuroprotection as well as superior DNA protection and repair, unmatchable by any other antioxidant. Studies show that DHLA increases cellular energy and efficiency by increasing ATP. At the same time, DHLA helps regenerate the production of vitamin E, CoQ10, glutathione, NADH and NADPH to provide unparalleled DNA protection. In addition, DHLA has the capacity to induce repair of DNA strand breaks.For long-term benefits of DHLA, only natural-source DHLA is recommended to avoid the long-term degradation of DNA from synthetically-derived sources.

Arterial and Heart Protection
Research has shown that DHLA can accelerate recovery of the aortic blood flow during reperfusion (resumption of blood flow) and increase ATP synthesis in the rat heart ALA forms were not helpful — only internally generated DHLA was able to reduce the infarct or necrotic tissue size in middle cerebral artery occlusion in mice ALA must be reduced to the DHLA form in order to provide neuroprotection. Natural-source, stabilized DHLA (now available) can provide exquisite neuroprotection as well as superior DNA repair and protection without compromise.

DHLA: Safety and Effectiveness
Clinical research by Dr. Robert J. Marshall has shown that the newly available natural-source, stabilized DHLA is both safe and effective for general use, including those with chronic illness and neurodegenerative disease. If high dosages (over 300 mg/day) of stabilized DHLA are used, to get maximum benefits the concurrent use of additional nutrients such as nutritional yeast which contains natural-source B vitamins, sulphur-based amino acids and reduced glutathione, is an excellent adjunct.

*Disclaimer:  The FDA has not evaluated any of these statements.  Practice at your own risk and gain.  Please seek immediate medical care for any urgent trauma. This product is not intended to diagnose, treat, cure or prevent any disease.